Immunologic goalposts for TB vaccine development
نویسندگان
چکیده
منابع مشابه
Progress and challenges in TB vaccine development
The Bacille Calmette Guerin (BCG) vaccine can provide decades of protection against tuberculosis (TB) disease, and although imperfect, BCG is proof that vaccine mediated protection against TB is a possibility. A new TB vaccine is, therefore, an inevitability; the question is how long will it take us to get there? We have made substantial progress in the development of vaccine platforms, in the ...
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There is an urgent need for an immunological correlate of protection against tuberculosis (TB) with which to evaluate candidate TB vaccines in clinical trials. Development of a human challenge model of Mycobacterium tuberculosis (M.tb) could facilitate the detection of such correlate(s). Here we propose a novel in vivo Bacille Calmette-Guérin (BCG) challenge model using BCG immunization as a su...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2021
ISSN: 1931-3128
DOI: 10.1016/j.chom.2021.01.011